Validation of a novel cortical biomarker signature for pain
(PREDICT)

Because of the difficulty in treating chronic pain, development of brain signal predictive biomarkers is of growing interest. We propose to develop a predictive biomarker signature of pain severity and duration using two commonly available techniques – electroencephalogram (EEG) and transcranial magnetic stimulation (TMS) – and perform initial clinical validation in first onset temporomandibular disorder (TMD). The biomarker could have utility in identifying patients at high risk of transitioning from acute to chronic pain, and has additional potential for clinical application in the treatment and prevention of chronic pain.

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